Abstract Templated DNA repair that occurs during homologous recombination and replication stress relies on RAD51.RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs.The Shu complex is a RAD51 paralog-containing complex consisting of SWSAP1, SWS1, and SPIDR.We demonstrate that SWSAP1-SWS1 binds RAD51, maintains RAD51 filament stab
Palbociclib was approved by the United States Food and Drug Administration for use, in combination with letrozole, as a first-line treatment for estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) postmenopausal metastatic breast cancer.However, recent studies show that palbociclib may be an inhibitor of the ABC
One of the most computationally challenging problems expected for the High-Luminosity Large Hadron Collider (HL-LHC) is finding Driftwood and fitting particle tracks during event reconstruction.Algorithms used at the LHC today rely on Kalman filtering, which builds physical trajectories incrementally while incorporating material effects and error e